Alternative medicine from natural has been proven throughout the years to be very powerful in helping illnesses where modern medicine could not. Even doctors could not explain why patients get good results from alternative medicine.

One of the famous trend out there today is alternative medicine from the plant mangosteen. Mangosteen has been said to be one of the top ten trends to be watch. Mangosteen has emerged on to the eye of the market because of its powerful elements that includes polysaccharides (found in aloe vera), catechins (found in green tea), proanthocynadins (found in grape seeds), sterols and natures most powerful antioxidant Xanthones.

To be precise, there are 44 types of xanthones in the mangosteen and is you take the fruit constantly but don’t feel the greatness, it is because you are not geeting the Xanthones which is FOUND IN THE SKIN OF THE MANGOSTEEN.

Xanthones have strong qualities in providing nutrient to the human’s cell allowing it to do its task. This is proven because the fruit has been used in folk lore medicine centuries ago.

On the scientific side, studies have demonstrated that xanthones have the ability to offer support in the following areas:

Cholesterol concerns  1,2

Inflammation / pain response /
Cox 2 inhibition  3

Skin conditions  4

Microbiological balance  5

Allergy support  6

Immune system support  7

1. Free Radic Res 2000 Nov;33(5):643-59. Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin. Mahabusarakam W, Proudfoot J, Taylor W, Croft K. Chemistry Department, Prince of Songkla University, Hat Yai, Thailand.

2. Williams P, Ongsakul M, Proudfoot J, Croft K, Beilin L. 1994. Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Rad Res. 23:175-184.

3. Biochem Pharmacol 2002 Jan 1;63(1):73-9.  Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y.  Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, 980-8578, Sendai, Japan.

4. Farnsworth N. 1992. Thai Medicinal Plants. Bangkok, Thailand: Medicinal Plant Information Center, Faculty of Pharmacy, Mahidol University.

5. Planta Med 1983 May;48(1):59-60. Antimicrobial activities of Garcinia mangostana.

Sundaram BM, Gopalakrishnan C, Subramanian S, Shankaranarayanan D, Kameswaran L.

6. Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant.

Nakatani K, Atsumi M, Arakawa T, Oosawa K, Shimura S, Nakahata N, Ohizumi Y. o Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

7. J Med Assoc Thai 1997 Sep;80 Suppl 1:S149-54. Immunopharmacological activity of polysaccharide from the pericarb of mangosteen garcinia: phagocytic intracellular killing activities. Chanarat P, Chanarat N, Fujihara M, Nagumo T.

Department of Clinical Microscopy, Faculty of Associated Medical Sciences, Chiang Mai University, Thailand.

8. Peres V, Nagem T, Faustino de Oliveira F. 2000. Tetraoxygenated naturally occurring xanthones. Phytochemistry. 55:683-710

(source: www.pubmed.gov)
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Well, im not a scientist but you can see lots of testimonials out there in the internet. Just search for it on Google.

The best part is that there are even a business opportunity that is based on this fruit and this company is changing peoples live all around the whole. in the end of the day, everyone wants to be wealthy and wealthy and there is just the right company let you do just that. The company is called XanGO. The category creator for the whole fruit mangosteen pureed juice.

Have a wonderful day!

Justin Wong
www.JustinWongCH.com

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How It Works

Various studies have shown that phytoceuticals in Mangosteen (in some cases known to be its xanthones) have properties such as: anti-tumor (shrinks tumors), anti-leukemia, antifungal (critical for all cancer patients), antibacterial (to protect DNA), antioxidants (at least two dozen different kinds of xanthones are in the mangosteen fruit), antiproliferation, kills cancer cells and causes apoptosis (programmed cell death) for some types of cancer. This is a pretty impressive list of cancer credentials!

Mangosteen Treatment

In keeping with the superb anti-cancer properties of many kinds of fruits, especially grapes and berries, mangosteen can be added to this exclusive list.

The mangosteen fruit (Garcinia mangostana L.) is grown in Thailand, Cambodia, Vietnam, India and several other countries. Most of the scientific research on this fruit involves about a half dozen of the two dozen known xanthones in this fruit. Most of the xanthones in Mangosteen have yet to be researched. Mangosteen has a wide range of benefits, perhaps most result from its xanthone phytoceuticals/antioxidants. However, mangosteen also contains: catechins, polyphenols, minerals and vitamins.

As an antioxidant, mangosteen is very high among plants:

• “A new laboratory test known as ORAC (Oxygen Radical Absorbance Capacity) has also shown that an ounce of mangosteen juice has 20 to 30 times the ability to absorb free radicals than one ounce of most fruits and vegetables. The ORAC test is one of the most accurate ways to measure the ability of antioxidants in a certain substance to absorb free radicals. The higher the ORAC score, the better the food is for the body.”
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Here are some of the xanthones in mangosteen:
alpha-Mangostin
beta-Mangostin
3-Isomangostin
Mangostanol
Gertanin
Garcinone A
Garcinone B
Garcinone C
Garcinone D
Garcinone E
Maclurin

In terms of direct studies on cancer, the following quote is related to cancer:

• “We found that antiproliferative effect of CME [crude methanolic extract] was associated with apoptosis on breast cancer cell line by determinations of morphological changes and oligonucleosomal DNA fragments. In addition, CME at various concentrations and incubation times were also found to inhibit ROS production. These investigations suggested that the methanolic extract from the pericarp [skin] of Garcinia mangostana had strong antiproliferation, potent antioxidation and induction of apoptosis. Thus, it indicates that this substance can show different activities and has potential for cancer chemoprevention which were dose dependent as well as exposure time dependent.”
  “Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line,” by Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N.

Heres is another study:

• “Our results have shown that one of the xanthone derivatives which could be identified as garcinone E has potent cytotoxic effect on all HCC cell lines as well as on other gastric and lung cancer cell lines included in the screen. We suggest that garcinone E may be potentially useful for the treatment of certain types of cancer.”
  “Garcinone E, a Xanthone Derivative, has Potent Cytotoxic Effect Against Hepatocellular Carcinome Cell Lines” by Chi-Kuan Ho, Yu-Ling Huang and Chieh-Chih Chen

Some of the more impressive research on mangosteen involve leukemia:

• “We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.”
  “Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines,” by Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.

Important Warning: Due to the fact that many cancer patients have liver damage, frequently due to chemotherapy, and due to the fact that high doses of this product may, in rare cases, contribute to liver damage; doses of this product should not exceed 3 or 4 ounces a day. Those who already have liver damage should avoid this product.

Note:  Xanthones are found mostly in the skin of the mangosteen and it is important that you are able to look for mangosteen products that includes the skin in it

For more details on the whole fruit pureed mangosteen juice, click here

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The Mangosteen Fruit has been use since thousand years ago as a traditional medicine. It is has been said that it is one of the top ten trends to be watch in the world right.  Lets take a look on the scientific side of this amazing fruit. Research has found amazing properties from this fruit and here is what the mangosteen can offer to you

Xanthones

Xanthones, which are unique to the mangosteen, as a class of phytonutrients are polyphenolic bioflavonoids. Over 60 research papers show antitumor, antiproliferative, antimicrobial, antihistamine, antiflammatory, antioxidant and gastrointestinal protective effects.

Proanthocyanidins

Proanthocyanidins present in the mangosteen as in grape seeds and skins and pine bark extract, have numerous qualities considered to be valuable in both the prevention of disease and the restoration of homeostasis (healthful balance) when disease is present. Hundreds of papers document the antitumor, antiproliferative, antimicrobial, antioxident and neuroprotective effects of proanthocyanidins.

Catechins

Catechins are active ingredients in green tea as well as mangosteen. Hundreds of papers detailing the benefits of catechins exist. They document antitumor, antimicrobial, antioxidant, anti-inflammatory and neuroprotective effects.

Polysaccharides

Polysaccharides known to have beneficial health effects, are very plentiful in the mangosteen. Since the molecular footprint of the fruit has not yet been traced, we cannot, at this time, specify which polysaccharides are in the plant.

Sterols

Sterols are plant lipids or fats. The best known supplement in this class is omega 3 fatty acid. The sterols of the mangosteen are found in its seeds. For the moment, insufficient research exists to allow further scientific comment on the mangosteen sterols.

Fiber

Fiber while not strictly a phytonutrient, is nonetheless important in the maintenance of gastrointestinal health. In the whole mangosteen fruit significant amounts of fiber are obvious.

For detailed reports about studies on mangosteen, check at www.pubmed.gov

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Xanthones

Definition:

Xanthones are a newly discovered, class of biologically active polyphenolic compounds structurally similar to bioflavonoids.

In nature, xanthones are very restricted in occurrence. The majority of them are found in just two families of higher plants – Guttiferae and Gentianaceae. Over 200 naturally occurring xanthones have been identified so far. Approximately 40 of those are found in the mangosteen.

Structure:

Xanthones are biologically active molecules with a six-carbon conjugated ring structure characterized by multiple double carbon bonds. The bonds make the xanthone molecule very stable.

All xanthones possess the same structural backbone. What makes the various xanthones unique are the side chains bound to the carbon molecules.

As examples of the xanthone’s versatility, note the various side chains that can be attached to the backbone.
Alpha mangostin, gamma mangostin, and Garcinone E are just three of the close to 40 xanthones in the mangosteen that provide the fruit with many of its medicinal properties.

Known Benefits:

Xanthones appear to possess numerous potential beneficial properties such as, “antiallergic, anti-inflammatory, antituberculotic, antitumor, antiplatelet, Betaadrenergic blocking and … anticonvulsant” properties. (Marona H, Pekala E, Filipek B, Maciag D, Szneler E. Pharmacological properties of some aminoalkanolic derivatives of xanthone. Pharmaxie. 2001;56:567-572)

More recent research has revealed that, while the xanthones appear to be the most nutritionally important elements in the mangosteen fruit, catechins, polysaccharides, proanthocyanidins and sterols also play major roles in providing the fruit with its unmatched medicinal qualities.

“Xanthones show considerable biological activity, and it is surprising that none has an established use in medicine.” (Taylor, Frost. Phytochemical Dictionary; 1983.)

Source: www.mangosteenmd.com

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Establishing a mangosteen dosing regimen can create robust health and vitality, preventing many illnesses from striking in the first place.

WHOLE BODY HEALTH

1. Strengthen the immune system. The flavonoids & flavones boost other antioxidants, including vitamins C & E, to a more protective level.
2. Combats inflammation. Helps prevent tissue swelling which can lead to many debilitating diseases & conditions.
3. Improves cell communication. The xanthones in mangosteen improve the body’s cell to cell communication to fight disease from attacking & spreading. It also speeds up healing & repair.
4. Thwarts DNA damage. Xanthones have been shown to thwart DNA damage, lowering risks from carcinogens & mutagens.
5. Aids the lymphatic system. Helps the lymphatic system eliminate cell waste.
6. Keeps thyroid functioning optimally. Mangosteen’s energy boosting ability helps overcome low thyroid conditions.
7. Reduces insulin resistance. Xanthones can help normalize blood sugar levels.
8. Helps lower body fat. Balances cortisol which can stimulate fat deposits in various parts of the body.
9. Heals nerve damage. The anti-neuralgic & anti-inflammatory properties help repair cellular damage that causes neurological pain & discomfort, including diabetic neuropathy.

10.  Balances the endocrine system. Favorably affects the balance of hormones & other neurochemicals produced by the endocrine system.

11.  Aids body synergy. Mangosteen’s disease microbial-fighting abilities & immune system-strengthening qualities empower the entire body.

12.  Reduces hemorroids. Alleviates the pain & swelling caused by inflammation.

13.  Helps alleviate hypoglycemia. Counters fatigue brought on by low blood-sugar levels.

14.  Relieves psoriasis. Xanthones can help detoxify the liver, which can cause psoriasis.

15.  Helps heal lesions. Promotes rapid healing of topical wounds.

16.  Reduces pain of carpal tunnel syndrome. Stops hand and wrist pain by reducing inflammation.

17.  Relieves neurodermatitis. Mangosteen’s anti-inflammatory properties counteract this scaly & itching skin disorder.

HEART HEALTH

1. Helps prevent heart disease. Xanthones neutralize free radical damage which may play a role in the inflammatory process.
2. Strengthens blood vessels. Improves the flow of nutrients to the body’s cells.
3. Lowers LDL cholesterol. Since mangosteen inhibits free radical damage, it may help reduce LDL oxidation in the blood.
4. Reduces high blood pressure. Mangosteen’s ability to strengthen heart muscles & help you lose weight may lead to lower blood pressure.
5. Helps prevents arteriosclorosis. Mangosteen’s anti-inflammatory effect may reduce plaque buildup in artery walls.

1. DIGESTIVE HEALTH

1. Helps overcome acid reflux disease (GERD). Mangosteen’s antioxidants may help protect & repair the lower esophagus damaged by gastro-esophageal reflux disease (GERD). Its acid-suppression effects may reduce stomach content acidity.
2. Helps heal ulcers. Xanthones kill bad bacteria, fungi & parasites, including H-pylori, the ulcer-causing bacteria.
3. Relief for irritable bowel syndrome (IBS). Blocks IBS-causing serotonin in the digestive system.
4. Helps stop diarrhea. The anti-inflammatory & anti-bacterial properties of the rind or pericarp can stop diarrhea.
5. Can relieve Crohn’s disease. The anti-inflammatory properties can prevent the malabsorption of vital nutrients by preventing damage to the wall of the small intestine.
6. May prevent diverticulitis. Can prevent infections in the pockets that form in the lining of the colon.

13.  YOUTHFUL LIVING

1. Boosts energy; improves resilience & increase stamina. Mangosteen’s nutrients provide needed energy.
2. Slows the aging process. Mangosteen’s regenerative nutrients & strong antioxidants keep cells operating optimally.
3. Helps prevent dementia & Alzheimer’s. Mangosteen’s flavonoids can stop simple memory loss.
4. Helps prevent kidney stones. The alkaline quality of mangosteen helps neutralize stone-forming acids in the body.
5. Helps prevent Parkinson’s disease. Mangosteen’s antioxidant qualities prevent oxidation, a factor in Parkinson’s.
6. Reduces pain from arthritis . The anti-inflammatory effect can reduce pain.
7. Repairs damage from NSAID use. Mangosteen has been shown to block the H1 & H2 receptors (histamine molecules linked to allergies & the production of stomach acid) naturally. Its anti-inflammatory properties may reduce stomach acid & protect the stomach lining from acid damage.
8. Aids in eye function. The antioxidant abilities protect cells from the oxidative damage that leads to aging and disease.

FAMILY HEALTH

1. Lowers fever. By fighting inflammation, offering immune system support & hydration, mangosteen can help fight fever.
2. Fights food poisoning. Xanthones can destroy Salmonella typhi.
3. Soothes sore throats. Anti-inflammatory effect can offer relief.
4. Helps heal mouth & canker sores. The natural antibiotic, antiviral & antifungal ability combats the pathogens that cause these sores.
5. Fights bad breath. Antibacterial properties help fight bad breath caused by bacteria.
6. Helps lessen migraines. Mangosteen can potentially correct abnormal serotonin functions in blood vessels that lead to migraines.
7. Relieves toothache pain. Anti-inflammatory effect can help relieve this pain.
8. Acts as a natural sleep aid. Helps balance hormones, which aids in balancing the sleep cycle.
9. Improves ability to deal with stress. Helps balance hormones like cortisol, which is overproduced during stress.

10.  Improves mood & reduces depression. Acts as a “mood elevator” by correcting brain chemical imbalances.

11.  Aids muscles and joint health. Pain can be reduced by the anti-inflammatory properties of mangosteen.

12.  Helps clear acne & skin blemishes. The detoxifying & anti-inflammatory properties of mangosteen can prevent & clear up skin problems.

13.  Treats bug bites, burns & poisonous plant contact. When made into a paste, the anti-bacterial & anti-inflammatory properties can relieve pain & swelling.

14.  Relieves sprained & strained muscles & ligaments. Mangosteen can be massaged onto skin for topical relief.

15.  Relieves stomachaches. Anti-bacterial and anti-inflammatory properties relieve stomachaches caused by bacterial infections.

16.  Relieves bronchitis, emphysema & pneumonia. Mangosteen’s anti-viral, anti-bacterial & anti-fungal effect can reduce the frequency of lung infections & other pulmonarydiseases.

17.  Works as a decongestant. Mangosteen’s anti-inflammatory properties help as a decongestant.

MEN’S HEALTH

1. Helps prevent male infertility. Mangosteen’s anti-inflammatory & anti-oxidant strengths can counter infertility due to stress, pollution & free radical-related factors.
2. Helps prevent prostate enlargement. The anitioxidant punch of mangosteen’s xanthones may be a powerful weapon in the fight against an enlarged prostate.

WOMEN’S HEALTH

1. Relieves urinary difficulties . The rind from mangosteen can relieve cystitis (inflammation of the bladder), caused by a bacterial infection.
2. Offers a gentle laxative effect . Unlike harsh laxatives that irritate the bowel, it heals and unblocks areas of bowel restriction.
3. Minimizes PMS . Reduces symptoms of moodiness & inflammation.
4. Relieves menopause symptoms . Removes stress from the body & helps maintain adequate levels of estrogen, thus slowing the effects of menopause.
5. Reduces menstrual swelling . The anti-inflammatory properties of mangosteen may counteract this bothersome side effect of PMS.
6. Reduces pain from fibromyalgia . Mangosteen exhibits a neurological pain-reducing effect.
7. Reduces pain from osteoporosis. Mangosteen’s neurological pain-reducing effect can offer relief from osteoporosis.

CHILDREN’S HEALTH

1. Helps relieve asthma. Mangosteen’s anti-viral, anti-bacterial & anti-fungal effect can reduce the frequency of lung infections & other pulmonary diseases.
2. May prevent ADHD & food allergies. Studies have found a strong connection between hyperactive behavior & food allergies. Mangosteen stops antigen/antibody reactions & reduces the body’s allergic reactions. It may also help reduce lead in children’s bodies which is linked to ADHD.
3. Builds stronger teeth and bones. Mangosteen aids in the efficient conversion of sunlight to vitamin D.

1. FIGHT DISEASE

1. Prevents gum disease. The anti-bacterial effect helps prevent gum disease.
2. Combat tuberculosis. Xanthones can overpower the bacteria responsible for causing TB.
3. Reduces lactose intolerance side effects. Mangosteen’s anti-inflammatory ability can reduce side effects, such as bloating & abdominal cramps.
4. Helps prevent dysentery. Effective fights Shigella, the bacterium that causes baciliary dysentery & the amoeba that causes amoebic dysentery..
5. Helps prevent multiple sclerosis (MS). Balances levels of tryptophan, serotonin and melatonin & prevents oxidative damage.
6. May thwart cancer. Xanthones have demonstrated anti-tumor properties in leukemia, liver, stomach & lung cancer, breast cancer & colon neoplasms.
7. Relieves Ankylosing Spondylitis (AS). Anti-inflammatory properties can relieve the cause of holes in the mucosal membrane, strengthening the body’s defenses.
8. Helps prevent cystic fibrosis (CF) infections. Mangosteen’s antioxidant & anti-microbial abilities may prevent excesss mucus found in CF.
9. Prevent lupus-related symptoms. Anti-inflammatory & autoimmune strengthening qualities can help lupus symptoms.
10. Counteracts Myasthenia Gravis. Counteracts the symptoms of this autoimmune disease by strengthening the immune system.

Source: Breakthroughs in Health, Vol. 1, Issue 5, 2006

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